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FLASH GENE
Symbol PEG10 contributors: mct/pgu - updated : 21-02-2012
HGNC name paternally expressed 10
HGNC id 14005
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CCHC type zinc finger motif
    • HOMOLOGY
    interspecies homolog to murine myelin expression factor 3
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text distributed in the cytosol and associates with the nuclear membrane
    basic FUNCTION
  • may play an important role during liver regeneration or carcinogenesis of the hepatocyte
  • decreasing the cell death mediated by SIAH1
  • plays a crucial role at the immediate early stage of adipocyte differentiation
  • showing significant oncogenic function in both solid tumors and B cell acute and chronic lymphocytic leukemia through its apparent ability to prevent apoptosis and promote cell proliferation
  • involved in the repression of apoptosis induced by serum deprivation and chemotherapeutic drugs
  • expressing two reading frames by high efficiency and frameshifting in embryonic-associated tissues
  • promote adipocyte differentiation
  • probable target, acting as a driving force for amplification of the 7q21 region, and may therefore be involved in the development or progression of hepatocellular carcinoma
  • play a role in fetal growth and placental development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SIAH1
  • E2F acts directly upstream of an anti-apoptosis imprinted gene, PEG10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a great majority of hepatocellular carcinomas
    tumoral     --over  
    from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia BCLL
    constitutional     --low  
    in third trimester downregulated in fetal samples group
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • represents a novel marker in B-CLL
  • for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)
    • Marker
  • positive expression of PEG10 or TSG101 is a predictor of poor prognosis in gallbladder adenocarcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)
    ANIMAL & CELL MODELS