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FLASH GENE

Symbol

PEG10

contributors: mct/pgu - updated : 21-02-2012

HGNC name	paternally expressed 10
HGNC id	14005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	codes for at least two proteins, PEG10-RF1 and PEG10-RF1/2, by -1 frameshift translation (PMID: 20084274)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015068 2 - 6628 NP_055883 - 708 - 2010 20084274 RF1/RF2 NM_001040152 2 - 6628 NP_001035242 - 325 - 2010 20084274 RF1 is an inhibitor of apoptosis and mediates cell proliferation NM_001184961 2 - 6628 NP_001171890 - 742 - 2010 20084274 RF1/RF2 NM_001040162 2 - 6628 NP_001171891 - 359 - 2010 20084274 RF1 is an inhibitor of apoptosis and mediates cell proliferation NM_001172437 2 - 6602 NP_001165908 - 784 - 2010 20084274 RF1/RF2 NM_001172438 2 - 6602 NP_001165909 - 401 - 2010 20084274 RF1 is an inhibitor of apoptosis and mediates cell proliferation

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive mouth tongue     highly Nervous brain       moderately Reproductive female system placenta     highly   female system ovary     highly   male system testis     highly Respiratory lung       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

IMPRINTING

maternally

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

CCHC type zinc finger motif

HOMOLOGY

interspecies

homolog to murine myelin expression factor 3

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	distributed in the cytosol and associates with the nuclear membrane

basic FUNCTION	may play an important role during liver regeneration or carcinogenesis of the hepatocyte
	decreasing the cell death mediated by SIAH1
	plays a crucial role at the immediate early stage of adipocyte differentiation
	showing significant oncogenic function in both solid tumors and B cell acute and chronic lymphocytic leukemia through its apparent ability to prevent apoptosis and promote cell proliferation
	involved in the repression of apoptosis induced by serum deprivation and chemotherapeutic drugs
	expressing two reading frames by high efficiency and frameshifting in embryonic-associated tissues
	promote adipocyte differentiation
	probable target, acting as a driving force for amplification of the 7q21 region, and may therefore be involved in the development or progression of hepatocellular carcinoma
	play a role in fetal growth and placental development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with SIAH1
	E2F acts directly upstream of an anti-apoptosis imprinted gene, PEG10

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a great majority of hepatocellular carcinomas tumoral     --over   from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia BCLL constitutional     --low   in third trimester downregulated in fetal samples group

Susceptibility

Variant & Polymorphism

Candidate gene	represents a novel marker in B-CLL
	for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)
Marker	positive expression of PEG10 or TSG101 is a predictor of poor prognosis in gallbladder adenocarcinoma
Therapy target
	System Type Disorder Pubmed cancer digestive liver for the treatment of hepatocellular carcinomas(development of drug(s) inhibiting PEG10 activity could be a novel approach)

ANIMAL & CELL MODELS