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FLASH GENE
Symbol ZC3H7B contributors: mct - updated : 21-12-2021
HGNC name zinc finger CCCH-type containing 7B
HGNC id 30869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2H2-type zinc finger
  • at least five C3H1-type zinc fingers
  • three TPR repeats
  • a paxillin leucine-aspartate repeat (LD) motif
    • HOMOLOGY
    interspecies homolog to murine Zc3h7b (96.4pc)
    homolog to rattus Zc3h7b (96.1pc)
    Homologene
    FAMILY
  • zinc finger family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cellular partner of NSP3 involved in the nucleocytoplasmic localization of PABP-C1 (Harb 2008)
    • CELLULAR PROCESS nucleotide, transcription
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with rotavirus non-structural protein NSP3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ZC3H7B-BCOR gene fusion has been described in a subset of myxoid high-grade endometrial stromal sarcomas
    tumoral fusion      
    ZC3H7B-BCOR fusion in myxoid smooth muscle neoplasia of the uterus
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS