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FLASH GENE

Symbol

ZC3H7B

contributors: mct - updated : 21-12-2021

HGNC name	zinc finger CCCH-type containing 7B
HGNC id	30869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	58.58 kb     23 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017590 23 - 5868 NP_060060 - 977 - 2008 18799579

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     predominantly   stomach       moderately Lymphoid/Immune lymph node       highly Nervous brain       moderately Reproductive female system uterus cervix   highly   female system breast mammary gland   moderately Skin/Tegument skin       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C2H2-type zinc finger
	at least five C3H1-type zinc fingers
	three TPR repeats
	a paxillin leucine-aspartate repeat (LD) motif

HOMOLOGY

interspecies	homolog to murine Zc3h7b (96.4pc)
	homolog to rattus Zc3h7b (96.1pc)

Homologene

FAMILY

zinc finger family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

cellular partner of NSP3 involved in the nucleocytoplasmic localization of PABP-C1 (Harb 2008)

CELLULAR PROCESS	nucleotide, transcription
	protein, translation regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

interacting with rotavirus non-structural protein NSP3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       ZC3H7B-BCOR gene fusion has been described in a subset of myxoid high-grade endometrial stromal sarcomas tumoral fusion       ZC3H7B-BCOR fusion in myxoid smooth muscle neoplasia of the uterus

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS