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FLASH GENE
Symbol TRAPPC2 contributors: mct/npt - updated : 31-01-2017
HGNC name trafficking protein particle complex 2
HGNC id 23068
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven SEDLP
    • HOMOLOGY
    interspecies homolog to murine Trappc2 (97.1 pc)
    Homologene
    FAMILY
  • TRAPP small subunits family
  • sedlin subfamily
    • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • perinuclear structure partly overlapping with the intermediate ER-Golgi compartment (ERGIC)
  • be present in both soluble
    • cytoplasmic fraction and in the membrane fraction (Choi 2009)
    basic FUNCTION
  • playing a putative role in endoplamsic reticulum (ER) to Golgi vesicular transport
  • preventing MBP1-mediated transcriptional repression
  • antagonizing MBP1-mediated cell death
  • nucleus-localized TRAPPC2 may play a role in regulation of transcriptional activities of the MRG family of transcription factors via binding to MRFAP1
  • joint action of MIA3 and TRAPPC2 sustained the ER export of Procollagen (PC), and its derangement may explain the defective chondrogenesis underlying SEDL
    • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport , ossification
    text skeletal development
    PATHWAY
    metabolism
    signaling
    a component
  • part of the multisubunit TRAPP (transport protein particle) complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAPPC2 is physically associated with protein associated with MRG 14 kDa (MRFAP1), a nuclear protein that interacts with the transcription factor MORF4L1
  • interaction with the transcription factors ENO1, PITX1 and SF1
  • associates with the RAB8A N-terminal domain and its subunits colocalize with centrosomal RAB8A and are required for RAB8A preciliary targeting and ciliogenesis
  • MIA3 recruited TRAPPC2, a TRAPP component and TRAPPC2 was required for the ER export of Procollagen (PC)
  • bound and promoted efficient cycling of SAR1A, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate PC prefibrils
  • interact with HIVEP1, a repressor of the MYC promoter (pMID: 24098805)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SEDL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    simultaneous targeting of NCAPG2 and TRAPPC2 is a promising strategy for the development of antitumor drugs as a treatment for intractable tumours
    ANIMAL & CELL MODELS