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FLASH GENE
Symbol GNA15 contributors: mct - updated : 21-09-2016
HGNC name guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HGNC id 4383
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain with three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • beta3 region of GNA16 is essential for interaction with TTC1 and the subsequent activation of RAS, but has relatively minor influence on the PLCB1 interaction
    • HOMOLOGY
    Homologene
    FAMILY G-alpha family, G(q) subfamily
    CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle
    basic FUNCTION
  • mediating pertussis toxin-resistant stimulation of phospholipase C beta
  • involved as modulators or transducers in various
    • transmembrane signaling systems
  • GNA15 regulates multiple signaling pathways by activating RAS through its association with TTC1, but TTC1 is not required for GNA15 to stimulate PLCB1
  • may utilize different structural domains to bind TTC1 and PLCB1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • GNA15 associate with tetratricopeptide repeat 1 (TTC1), an adaptor protein which preferentially binds to RAS
  • GNA15 can signal through TTC1/RAS and PLCB1 simultaneously and independently
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS