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FLASH GENE
Symbol GNA15 contributors: mct - updated : 21-09-2016
HGNC name guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HGNC id 4383
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 salivary gland   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemovary  highly
 male systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain with three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • beta3 region of GNA16 is essential for interaction with TTC1 and the subsequent activation of RAS, but has relatively minor influence on the PLCB1 interaction
    • HOMOLOGY
    Homologene
    FAMILY G-alpha family, G(q) subfamily
    CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle
    basic FUNCTION
  • mediating pertussis toxin-resistant stimulation of phospholipase C beta
  • involved as modulators or transducers in various
    • transmembrane signaling systems
  • GNA15 regulates multiple signaling pathways by activating RAS through its association with TTC1, but TTC1 is not required for GNA15 to stimulate PLCB1
  • may utilize different structural domains to bind TTC1 and PLCB1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • GNA15 associate with tetratricopeptide repeat 1 (TTC1), an adaptor protein which preferentially binds to RAS
  • GNA15 can signal through TTC1/RAS and PLCB1 simultaneously and independently
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS