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FLASH GENE
Symbol CTSF contributors: npt/mct - updated : 28/11/2008
HGNC name cathepsin F
HGNC id 2531
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • resulting from a gene fusion between an ancestral cystatin and cathepsin
  • a hydrophobic signal sequence
  • a long propeptide domain
  • a ERFNAQ motif
  • a catalytic region including an essential cysteine residue
  • a signal peptide targeting CTSF to the lysosomal compartment
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase C1 family
  • papain cysteine protease (C1) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • cysteine proteinase, involved in degradative processes during tumor progression
  • play a central role on the enhancement of tumor-induced angiogenesis, cell migration, proliferation, apoptosis and connective tissue degradation
  • with angiotensin II participate in atherosclerosis, particularly in remodeling of the extracellular matrix of the inflamed arterial intima
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text proteolysis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS