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FLASH GENE
Symbol SSTR1 contributors: mct - updated : 16-09-2017
HGNC name somatostatin receptor 1
HGNC id 11330
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins
  • in an appropriate cellular environment, can functionally couple to the inhibition of adenylyl cyclase
  • SSTR1, SSTR2 may have important functional roles in the inner ear
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • could both homodimerize and heterodimerize with SSTR5 in the presence of the agonist SST14 (activation of SSTR5 but not SSTR1 is necessary for heterodimeric assembly)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with SKB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the majority of pancreatic cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS