Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SSTR1

contributors: mct - updated : 16-09-2017

HGNC name	somatostatin receptor 1
HGNC id	11330

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

signaling hormone , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	stimulating phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins
	in an appropriate cellular environment, can functionally couple to the inhibition of adenylyl cyclase
	SSTR1, SSTR2 may have important functional roles in the inner ear

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

could both homodimerize and heterodimerize with SSTR5 in the presence of the agonist SST14 (activation of SSTR5 but not SSTR1 is necessary for heterodimeric assembly)

INTERACTION

DNA

RNA

small molecule

protein

interacts with SKB1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the majority of pancreatic cancer tissue

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS