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FLASH GENE

Symbol

SSTR1

contributors: mct - updated : 16-09-2017

HGNC name	somatostatin receptor 1
HGNC id	11330

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.07 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	promoter region lacked consensus sites for TATA or CAAT boxes, YY1, or an initiator sequence, but contained two CpG islands, and several putative transcription factor binding sites inducing the cell-type specific activity

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001049 3 - 4343 NP_001040 42.5 391 - 1993 8405411

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Mus musculus Fetal Nervous brain limbic system hippocampus     Homo sapiens   brain forebrain cerebral cortex     Homo sapiens   spinal cord         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

signaling hormone , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	stimulating phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins
	in an appropriate cellular environment, can functionally couple to the inhibition of adenylyl cyclase
	SSTR1, SSTR2 may have important functional roles in the inner ear

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

could both homodimerize and heterodimerize with SSTR5 in the presence of the agonist SST14 (activation of SSTR5 but not SSTR1 is necessary for heterodimeric assembly)

INTERACTION

DNA

RNA

small molecule

protein

interacts with SKB1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the majority of pancreatic cancer tissue

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS