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FLASH GENE
Symbol CD4 contributors: mct/npt - updated : 25-04-2017
HGNC name CD4 molecule
HGNC id 1678
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four modular ectodomains (D1-D4) (Ashish 2008)
  • an extracellular domain of 370 AAs
  • a short transmembrane region
  • a cytoplasmic domain of 40 AAs at the C-terminal end (Wittlich 2007)
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • Ig superfamily
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane glycoprotein (Wittlich 2007)
    basic FUNCTION
  • HIV and MHC class II receptor
  • CD4-induced aggregation of lipid rafts may play an additional role in CD4 signaling besides its adhesion to MHC molecules (Fragoso 2003)
  • plays essential roles in the immune defence and in T lymphocytes, with PTK2 localise to the same signalling complexes after stimulation by either the human immunodeficiency virus (HIV) gp120 glycoprotein or an antigen (Garron 2008)
  • glycoprotein involved in T-cell development and antigen recognition (Achour 2009)
  • role of CD4, which contributes to regulating CCR5 export to the plasma membrane (Achour 2009)
    • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell interaction
    a component
  • constituent of transmembrane glycoprotein
  • PTK2-CD4 complex represents an alternative route for eliciting T-cell-specific signals and it links gp120 engagement to distinctive T-cell signalling during HIV infection (Garron 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activated LCK, through T cell receptor
  • leading to BAX increase and mitochondrial damage in the absence of VAV exchange factor
  • interacting with PLSCR1 and SLPI (the same region of the cytoplasmic domain of PLSCR1 is involved in the binding to CD4 and SLPI) (Py 2009)
  • CCR5-CD4 association, which occurs in the endoplasmic reticulum, enhanced CCR5 export to the plasma membrane in a concentration-dependent manner, whereas inhibition of endogenous CD4 with small interfering RNAs decreased cell-surface expression of endogenous CCR5 (Achour 2009)
  • binding PTK2 (Garron 2008)
  • modulates reversible and epigenetic silencing of the CD4 gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in striatum and caudate from HD patients Mazarei 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS