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FLASH GENE

Symbol

PDS5B

contributors: mct - updated : 05-12-2017

HGNC name	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
HGNC id	20418

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	191.56 kb     35 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

downstream of BRCA2 and centromeric to the retinoblastoma locus (RB1)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015032 35 - 7498 NP_055847 165 1447 - Nagase, Osada (2005)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala   highly   spinal cord

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a coiled-coil structure and a leucine zipper
	nuclear localization signals (NLS)
	proline and serine rich domain
	unique C terminal acidic-basic repeats
	ATP and DNA binding motifs
	protein kinase motif

HOMOLOGY

Homologene

FAMILY

PDS5 family

CATEGORY

DNA associated , tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
text	expression is precisely coordinated with stem cell differentiation and is critical in stem/progenitor exit decisions (Denes 2010)

basic FUNCTION	step2, proliferative shutoff in the regulation of prostate gland cell members,in the BRCA2, RB1 region
	may be a new suppressor gene in relation with prostate cancer
	PDS5A and PDS5B functions other than those involving chromosomal dynamics are important for normal development, highlights the sensitivity of key developmental processes on PDS5 signaling (Zhang 2009)
	cohesin dynamics are controlled by the releasing factors PDS5B and WAPL and the cohesin stabilizer CDCA5

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	negative control of cell proliferation

PATHWAY

metabolism

signaling

a component

WAPL is a key negative regulator of cohesin and forms a complex with precocious dissociation of sisters protein 5 (PDS5A, PDS5B) to promote cohesin release from chromatin

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	role for NEK1 in the regulation of WAPL loading during meiotic prophase I, via an interaction between NEK1 and PDS5B
	HASPIN-PDS5B interaction is required to ensure proper sister-chromatid cohesion, most likely through antagonizing WAPAL-mediated cohesin release from mitotic centromeres
	strong centromere cohesion requires centromeric localization of the mitotic histone kinase HASPIN, which is dependent on the interaction of its non-catalytic N-terminus with PDS5B

cell & other

REGULATION

activated by

upregulated during androgen-induced proliferative shutoff

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in esophageal squamous cell carcinoma with lymph node metastasis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS