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FLASH GENE

Symbol

PFKFB4

contributors: - updated : 19-09-2007

HGNC name	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
HGNC id	8875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p22-p21      Physical location : 48.555.125 - 48.594.227
Synonym name	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4
	bifunctional enzyme with kinase and biphosphatase activities
EC.number	2.7.1.105

DNA

TYPE	functioning gene
STRUCTURE	39.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3503 - 469 - Minchenko variant 3 - - 1733 - 435 - Minchenko variant 4 - - 1724 - 278 - Minchenko variant 5 - - 1491 - 434 - Minchenko

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve cranial nerve     highly Reproductive male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	responsible for the synthesis and breakdown of fructose 2,6 biphosphate
	key metabolite in the regulation of glycolysis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS