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FLASH GENE

Symbol

FKBP2

contributors: - updated : 31-12-2005

HGNC name	FK506 binding protein 2, 13kDa
HGNC id	3718

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.1      Physical location : 64.008.412 - 64.011.606
Synonym name	FK506 binding protein 2 (13kD)
Synonym symbol(s)	FKBP13
EC.number	5.2.1.8

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Variant 1 - - 810 16 142 - - Variant 2 - - 710 16 142 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal FK506 binding and peptidyl prolyl cis-trans isomerase (rotamase) domains
	three tetratricopeptide repeat (TPR) motifs consistent with nuclear transcript or chaperone activity

HOMOLOGY

Homologene

FAMILY

immunophilin class of proteins family

CATEGORY

chaperone/stress , enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	T cell binding protein FKBP-13 for the immunosuppressive agents FK506-rapamycin
	immunophilin class of protein with intrinsic peptidyl-prolyl cis-trans isomerase activity

CELLULAR PROCESS

protein, post translation, folding

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding erythroid membrane protein bond 4.1 (or on homolog)

cell & other

REGULATION

inhibited by

FK506 and rapamycin

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS