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FLASH GENE
Symbol C14orf1 contributors: mct - updated : 23-03-2016
HGNC name chromosome 14 open reading frame 1
HGNC id 1187
Location 14q24.3      Physical location : 76.117.233 - 76.127.538
Synonym symbol(s) C8A3, ERG28, NET51
DNA
TYPE functioning gene
STRUCTURE 10.31 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D14S71 - [D14S76 - D14S273 - D14S61 - C14orf1 - D14S270 - D14S263 - D14S929 - D14S254 - D14S74 ,D14S61 ,D14S68 - D14S73 ] - qter
Authors Veitia (99)
Text [renal cell carcinoma, meningioma, neuroblastoma, colon carcinoma], see TSG14B
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1576 - 140 - 2001 11160377
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines colorectal cancer cell lines (see TSG14B)
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
highly basic protein with putative transmembrane domains
HOMOLOGY
interspecies homolog to yeast Yer044C
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • involved in sterol biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • . partners of CLN8 are VAPA, C14orf1/hERG28, STX8, GABARAPL2, BNIP3 and BNIP3L proteins and are associated with biologically relevant processes such as synthesis and transport of lipids, vesicular/membrane trafficking, autophagy/mitophagy and apoptosis
  • IER3IP1, PPIB, EMC7, SPINT2, C14orf1/PEBP28, TMEM147, YIPF6, and KCP2 interacting with SLC41A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS