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FLASH GENE

Symbol

C14orf1

contributors: mct - updated : 23-03-2016

HGNC name	chromosome 14 open reading frame 1
HGNC id	1187

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q24.3      Physical location : 76.117.233 - 76.127.538
Synonym symbol(s)	C8A3, ERG28, NET51

DNA

TYPE	functioning gene
STRUCTURE	10.31 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D14S71 - [D14S76 - D14S273 - D14S61 - C14orf1 - D14S270 - D14S263 - D14S929 - D14S254 - D14S74 ,D14S61 ,D14S68 - D14S73 ] - qter
Authors	Veitia (99)
Text	[renal cell carcinoma, meningioma, neuroblastoma, colon carcinoma], see TSG14B

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007176 5 - 1576 NP_009107 - 140 - 2001 11160377

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage
cell lines	colorectal cancer cell lines (see TSG14B)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

highly basic protein with putative transmembrane domains

HOMOLOGY

interspecies

homolog to yeast Yer044C

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION

involved in sterol biosynthesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	. partners of CLN8 are VAPA, C14orf1/hERG28, STX8, GABARAPL2, BNIP3 and BNIP3L proteins and are associated with biologically relevant processes such as synthesis and transport of lipids, vesicular/membrane trafficking, autophagy/mitophagy and apoptosis
	IER3IP1, PPIB, EMC7, SPINT2, C14orf1/PEBP28, TMEM147, YIPF6, and KCP2 interacting with SLC41A1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS