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FLASH GENE

Symbol

ERLIN2

contributors: npt/shn/mct - updated : 06-01-2016

HGNC name	ER lipid raft associated 2
HGNC id	1356

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IDMDC , SPG18 , PLSJ2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   of ZNF703, ERLIN2, PROSC, GPR124, and BRF2 in urothelial carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer interfering with the ERLIN2/gamma-secretase interaction might reduce APP production without affecting Notch processing, and thus be a pharmacological strategy for treatment of AD

ANIMAL & CELL MODELS