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FLASH GENE
Symbol GYS1 contributors: mct/npt - updated : 06-03-2010
HGNC name glycogen synthase 1 (muscle)
HGNC id 4706
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
intraspecies paralog to GYS2
Homologene
FAMILY
  • glucosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • the rate limiting enzyme of the insulin-induced glycogenesis,transferring glucose units from UDP-Glc to a glycogen primer
  • catalyzes the linear addition of glucose residues to the branching structure of glycogen, providing a convenient store of glucose for times of metabolic need (Cameron 2009)
  • vital for glycogen synthesis in heart and muscle, giving a reserve of critical energy during bursts of activity, sustained muscle work and hypoxia (Cameron 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • a complex with GYG1 and TRIM7
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by phosphorylated by epinephrine or glucagon
    Other stimulated (dephosphorylated) by insulin
    ASSOCIATED DISORDERS
    corresponding disease(s) GYS1D
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS