SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,nucleus
|
| intracellular,nuclear envelope,int
|
text
| integral membrane zinc metalloprotease (Barrowman (2009) |
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membrane-associated enzyme that is predicted to contain seven transmembrane segments and is localized to the ER membrane and the inner nuclear membrane |
basic FUNCTION
| involved in the proteolytic processing of farnesylated proteins |
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catalyzing the first step of the proteolytic processing of farnesylated proteins, including Ras, and also involved in NH2 terminal processing |
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endoprotease essential for the post-translational cleavage of the Lamin A precursor and the production of mature LMNA |
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key protease involved in human progeroid disorder (Barrowman 2009) |
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performs a critical endoproteolytic cleavage step that removes the hydrophobic farnesyl-modified tail of prelamin A (Barrowman 2009) |
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plays a critical role in nuclear lamin biology by cleaving the prenylated and carboxylmethylated 15-amino acid tail from the C-terminus of prelamin A to yield mature lamin A ![](pubmed.jpg) |
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only metalloprotease, which transforms prelamin into mature lamin A ![](pubmed.jpg) |