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FLASH GENE
Symbol MID2 contributors: KTN/npt - updated : 02-02-2009
HGNC name midline 2
HGNC id 7096
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal RING finger
  • two B box domains, linked to a leucine coiled-coil domain (RBCC subgroup) the so-called tripartite motif (TRIM) mediating homodimerization, characteristic of the B box family of proteins, involved in cell proliferation and development
  • a COS (C-terminal subgrooup one signature) domain
  • a fibronectin type III domain between the RBCC
  • the C terminal B30-2/SPRY or RFP-like domain
    • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Mid2 (99.3 pc)
    homolog to rattus Mid2 (99.1 pc)
    intraspecies homolog to MID1
    Homologene
    FAMILY
  • TRIM/RBCC family
  • B box family TRIM subfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • playing a role in embryonic development
  • acting as an antiretroviral factor (Ozato 2008)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer with MID1 (Short 2002)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with IGBP1
  • interacting with PPP2R4 (Short 2002)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for X-linked FG (Opitz-Kaveggia) syndrome (Short 2002, Ozato 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS