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FLASH GENE

Symbol

MID2

contributors: KTN/npt - updated : 02-02-2009

HGNC name	midline 2
HGNC id	7096

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	100.96 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - BTK - DRP2 - GLA - TIMM8A - DXS101 - PLP1 - SERPINA7 - DXS1230 - DXS1120 - DXS6793 /MID2 - COL4A6 - COL4A5 - DXS1210 - PRPS1 PRPS1 - qter
Authors	Buchner (99) Perry (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 10 splicing 7345 isoform 1 83 735 - Buchner (1999) variant 2 10 splicing 7255 isoform 2 79.7 705 - Buchner (1999) lacking 90 nt form an internal exon

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	tissues, noteworthy in developing heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal RING finger
	two B box domains, linked to a leucine coiled-coil domain (RBCC subgroup) the so-called tripartite motif (TRIM) mediating homodimerization, characteristic of the B box family of proteins, involved in cell proliferation and development
	a COS (C-terminal subgrooup one signature) domain
	a fibronectin type III domain between the RBCC
	the C terminal B30-2/SPRY or RFP-like domain

conjugated

PhosphoP

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Mid2 (99.3 pc)
	homolog to rattus Mid2 (99.1 pc)

intraspecies

homolog to MID1

Homologene

FAMILY	TRIM/RBCC family
	B box family TRIM subfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	playing a role in embryonic development
	acting as an antiretroviral factor (Ozato 2008)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

heterodimer with MID1 (Short 2002)

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interacting with IGBP1
	interacting with PPP2R4 (Short 2002)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	for X-linked FG (Opitz-Kaveggia) syndrome (Short 2002, Ozato 2008)
Marker
Therapy target

ANIMAL & CELL MODELS