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FLASH GENE
Symbol RPH3AL contributors: - updated : 26-10-2005
HGNC name rabphilin 3A-like (without C2 domains)
HGNC id 10296
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 stomach    
Endocrinepancreas    
 thyroid    
Reproductivefemale systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative zinc finger protein motif
  • a conserved Rab3-binding domain (RBD3)
    • HOMOLOGY
    interspecies homolog to rattus Rph3al
    Homologene
    FAMILY
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton
    text cytoskeletal protein binding protein
    basic FUNCTION
  • involved in regulated endocrine exocytosis
  • involved in the recruitment of secretory granules at the plasma membrane possibly via the interaction with UNC13B
  • functioning as a potential RAB3B effector protein in epithelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein cytoskeletal protein binding protein(cytoskeleton LIM domain-containing protein zyxin)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS