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FLASH GENE
Symbol MSL3 contributors: mct - updated : 17-06-2011
HGNC name male-specific lethal 3 homolog (Drosophila)
HGNC id 7370
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two chromo domain : one at the N, the other at the C terminus
  • a canonical methyllysine binding pocket made up of residues Tyr-31, Phe-56, Trp-59, and Trp-63
  • a highly conserved N-terminal chromo-barrel domain (CBD) (residues 2–91
  • a conserved C-terminal MRG domain (residues 196–512) , responsible for interactions with MSL1, but does not interact directly with MYST1
    • HOMOLOGY
    interspecies homolog to Drosophila male-specific lethal 1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • role in chromatin remodeling and transcription regulation
  • essential for cell viability
  • plays an important role in targeting the male specific lethal complex to chromatin in both humans and flies by binding to H4K20Me(1)
  • may help to target the MSL complex to specific chromatin regions at least in part by binding to H4K20Me1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MSL1 interacts with MSL3 as an extended chain forming an extensive hydrophobic interface
  • interact directly with MYST1 via its conserved C-terminal MRG domain
    • cell & other
    REGULATION
    Other MSL function is regulated by a combination of post-translational modifications
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS