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FLASH GENE

Symbol

AFG3L2

contributors: mct - updated : 01-09-2015

HGNC name	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
HGNC id	315

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	loss of Afg3l2 in mouse embryonic fibroblasts (MEFs) reduces mitochondrial Ca2+ uptake capacity
	Afg3l2-/- mice resemble patients carrying homozygous mutations, showing a severe neurological syndrome that leads to lethality at P16