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FLASH GENE
Symbol LRRFIP1 contributors: mct - updated : 20-06-2012
HGNC name leucine rich repeat (in FLII) interacting protein 1
HGNC id 6702
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
coiled motifs that interact with the LRR domain of FLI
HOMOLOGY
interspecies homolog to murine Lrrfip1
homolog to Drosophila CG8507
intraspecies homolog to TAR RNA interacting protein
Homologene
FAMILY
CATEGORY regulatory , RNA associated , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
intracellular,nucleus
basic FUNCTION
  • providing a link between RNA and the actin cytoskeleton
  • transcriptional repressor overexpressed in cancer cell lines with a role in regulating expression of the EGFR
  • being the first TNF-alpha repressor identified
  • recruited to RNA-containing vesicles and potentilly participates in cell responses to virus at early time points, being important for type I IFN induction
  • functions as a component of the platelet cytoskeleton, where it interacts with the actin-remodeling proteins Flightless-1 and Drebrin
  • regulator of toll-like receptor (TLR) pathway signaling
  • potentially phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures
  • plays potentially an important role in colorectal cancer metastasis by regulating RHOA-induced cell adhesion, migration, and invasion
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to double-stranded GC-rich RNA
    small molecule
    protein
  • binding to FLI (leucine-rich repeat)
  • interacted directly with CTNNB1, GRIP1 and EP300 and enhanced their activity
  • MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity
  • interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3
    • cell & other
    REGULATION
    induced by phorbol esters
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to abdominal adiposity
    Variant & Polymorphism SNP rs11680012 was associated with abdominal adiposity (
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS