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FLASH GENE

Symbol

LRRFIP1

contributors: mct - updated : 20-06-2012

HGNC name	leucine rich repeat (in FLII) interacting protein 1
HGNC id	6702

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	154.07 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	specific alternatively spliced transcripts 3.9 and 2.8kb expressed in heart and skeletal muscle (Fong)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TRIP I1 NM_001137550 24 - 4109 NP_001131022 - 640 - 1999 10366446 TRIP I2 NM_001137551 12 - 3599 NP_001131023 - 394 - 1999 10366446 NM_001137552 11 - 4510 NP_001131024 - 808 - 1999 10366446 NM_004735 10 - 4438 NP_004726 86.4 784 - 1999 10366446 NM_001137553 8 - 4342 NP_001131025 - 752 - 1999 10366446

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Cardiovascular heart       highly Digestive liver       highly Endocrine pancreas       highly Nervous brain       moderately Reproductive male system testis     moderately Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic platelet Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	heart highly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

coiled motifs that interact with the LRR domain of FLI

HOMOLOGY

interspecies	homolog to murine Lrrfip1
	homolog to Drosophila CG8507

intraspecies

homolog to TAR RNA interacting protein

Homologene

FAMILY

CATEGORY

regulatory , RNA associated , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus

basic FUNCTION	providing a link between RNA and the actin cytoskeleton
	transcriptional repressor overexpressed in cancer cell lines with a role in regulating expression of the EGFR
	being the first TNF-alpha repressor identified
	recruited to RNA-containing vesicles and potentilly participates in cell responses to virus at early time points, being important for type I IFN induction
	functions as a component of the platelet cytoskeleton, where it interacts with the actin-remodeling proteins Flightless-1 and Drebrin
	regulator of toll-like receptor (TLR) pathway signaling
	potentially phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures
	plays potentially an important role in colorectal cancer metastasis by regulating RHOA-induced cell adhesion, migration, and invasion

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	transcription repressor

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding to double-stranded GC-rich RNA

small molecule

protein	binding to FLI (leucine-rich repeat)
	interacted directly with CTNNB1, GRIP1 and EP300 and enhanced their activity
	MYD88 interacting with LRRFIP2 and LRRFIP1, and both are positive regulators of NF-kappaB activity
	interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3

cell & other

REGULATION

induced by

phorbol esters

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to abdominal adiposity

Variant & Polymorphism SNP	rs11680012 was associated with abdominal adiposity (

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS