| Symbol
| CIZ1
| contributors: mct - updated : 05-03-2019
|
| HGNC name
| CDKN1A interacting zinc finger protein 1
|
| HGNC id
| 16744
|
| corresponding disease(s)
|
DTPC2
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
|
| |
aberrantly expressed in Ewing sarcoma | | constitutional
|
|
| --over
|
|
more highly expressed in Alzheimer tissue than in healthy brains  | | constitutional
|
|
| --over
|
| |
in hemangioma of the tongue while its expression is minimal in the normal tongue tissues | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| variant CIZ1 is a strong candidate for a cancer-specific single marker capable of identifying early-stage lung cancer within at-risk groups without resort to invasive procedures | |
overexpression of CIZ1 may contribute to the growth and angiogenesis of lung squamous cell carcinoma (LSCC), thus CIZ1 could represent a biomarker for diagnosis and a target for therapeutic intervention | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | digestive | liver | |
| CIZ1 might be a therapeutic target for HCC |
| | |
|
| germline knockout of Ciz1 is associated with motor and hematological abnormalities in young adult mice | |
Ciz1(-/-) mice did not manifest dystonia, but exhibited mild motoric abnormalities on balance, open-field activity, and gait |