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FLASH GENE

Symbol

ITGA9

contributors: SGE - updated : 30-07-2010

HGNC name	integrin, alpha 9
HGNC id	6145

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Muscular smooth       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage
cell lines	other cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	lung, highly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven FG-GAP repeats

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Itga9 (89.5pc)
	homolog to rattus Itga9 (90.0pc)

Homologene

FAMILY

integrin alpha chain family

CATEGORY

adhesion , receptor

SUBCELLULAR LOCALIZATION
text	type I membrane protein

basic FUNCTION	cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
	allows retinal pigmented epithelial cells adhesion on Bruch's membrane in wet age-related macular degeneration (Afshari 2010)
	can induce and localise to focal adhesions in a high activation state, whereas its intermediate activity state normally supports cell adhesion consistent with migration (Lydolph 2009)
	contributing to adhesion and differentiation of hematopoietic stem and progenitor cells in the endosteal stem cell niche (Schreiber 2009)
	critical intrinsic regulator that controls the development of autoimmune arthritis (Kanayama 2009)
	involved in the attraction of neutrophils via its binding to osteopontin (Nishimichi 2009)
	receptor for nerve growth factor, brain-derived neutrophic factor and NT3 (Staniszewska 2008)

CELLULAR PROCESS	cell communication
	cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

dimerizing with ITGB1

INTERACTION

DNA

RNA

small molecule

protein

EMILIN1 is a novel ligand for keratinocyte ITGA9, suggesting prospective roles for this receptor-ligand pair in skin homeostasis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     homozygously deleted in a lung cancer cell-line (Hibi 1994)

Susceptibility

Variant & Polymorphism

Candidate gene	is required for fibronectin matrix assembly during lymphatic valve morphogenesis, implicating it as a candidate gene for primary lymphedema caused by valve defects (Bazigou 2009)
Marker
Therapy target

ANIMAL & CELL MODELS