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FLASH GENE
Symbol HS3ST2 contributors: mct - updated : 28-08-2015
HGNC name heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HGNC id 5195
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five potential N-glycosylation sites
  • four domains
  • a N terminal cytoplasmic tail
  • an hydrophobic transmembrane segment
  • a domain extremely rich in Ser, Pro, Leu, Ala, Gly (SPLAG domain, acting as a flexible stem)
  • a putative C terminal conserved sulfotransferase domain
    • HOMOLOGY
    interspecies homolog to murine Hs3st2
    homolog to C.elegans hst-3
    Homologene
    FAMILY
  • sulfotransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    text integral membrane protein type II
    basic FUNCTION
  • heparan sulfate D-glucosamine 3-O-sulfotransferase 2
  • putative regulator of heparan sulfate proteoglycan properties
  • may play a role in the nervous system development
  • involved in glycosaminoglycan chain synthesis or modifications
  • HS2ST1 and HS3ST2 are novel regulators of breast cancer stem-cell properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS