protein
| interading with CARD4, CARD15 |
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with CASP1(stress-inducible upstream modulator of procaspase 1 apoptotic activation) |
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interacting with BCL10 and inducing its phosphorylation |
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determines its stability and consequently NOD1- and NOD2-mediated immune responses |
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interacts with XIAP via its BIR2 domain, which could be disrupted by XIAP antagonists SMAC and SMAC-mimicking compounds |
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interaction with XIAP (playing a role in regulating innate immune responses by interacting with NOD1 and NOD2) |
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target of activated receptors of the tumor necrosis factor receptor (TNFR) type, in myogenic differentiation and regeneration |
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XIAP ubiquitylates RIPK2 and recruits the linear ubiquitin chain assembly complex (LUBAC) to NOD2 |
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NOD2 stimulates autophagy in a process dependent on RIPK2 tyrosine kinase activity |
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INPP5D C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIPK2 in order to decrease NFKB1 signaling |
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NOD1 CARD binds ubiquitin (Ub), in addition to directly binding its downstream targets receptor-interacting protein kinase 2 (RIPK2) and autophagy-related protein 16-1 (ATG16L1) |
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interaction between TRAF3 and RIPK2 (TRAF3 could inhibit RIPK2-induced NFKB1 activation) |
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RIPK2 is a substrate for PELI3 and PELI3 is an important mediator in the NOD2 pathway and regulator of intestinal inflammation |