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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

HAND2

contributors: mct/npt/pgu/shn - updated : 06-12-2013

HGNC name	heart and neural crest derivatives expressed 2
HGNC id	4808

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Targeted deletion of the dHAND gene in mice revealed severe defects of embryonic and yolk sac vascular development by embryonic day 9.5
	Hand2 deletion in mouse nestin-expressing neural precursor cells impacts development of the enteric nervous system resulting in a marked disruption of the developing neural network, exemplified by lack of a myenteric plexus and extensive overgrowth of fibers