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FLASH GENE
Symbol CD3G contributors: mct - updated : 01-09-2017
HGNC name CD3g molecule, gamma (CD3-TCR complex)
HGNC id 1675
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig extracellular domain
  • a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM), isoform TAC12, 12kDa
  • three NFAT binding motifs (for NFATC1, NFATC2 and NFKB2)
  • highly evolutionarily conserved CXXC motif
  • a short extracellular stalk connecting its Ig-like domains to its transmembrane regions
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd3g
    homolog to C.elegans C02F5.5
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • mediating signal transduction
  • the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane
  • CD3G and CD3D evolved from a common precursor gene to optimize peptide/MHC-triggered alphabeta TCR activation
  • important role of the CD3G diL motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of the CD3 (pre-T cell and T cell) antigen receptor complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD17
    related resource CD3Gbase: Mutation registry for autosomal recessive CD3gamma immunodeficiency
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in patients with aplastic anemia (AA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS