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FLASH GENE

Symbol

CD3G

contributors: mct - updated : 01-09-2017

HGNC name	CD3g molecule, gamma (CD3-TCR complex)
HGNC id	1675

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	IMD17 Immunodeficiency 17, CD3 gamma deficient
Location	11q23.3      Physical location : 118.215.058 - 118.224.497
Synonym name	cell differentiation antigen CD3G (gp26), gamma polypeptide (see CD3@)
	CD3G antigen, gamma polypeptide (TiT3 complex)
	T-cell antigen receptor complex, gamma subunit of T3
	T-cell receptor T3 gamma chain
Synonym symbol(s)	TAC12, T3G, CD3-GAMMA

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, head to head
text	see CD3@
	head to head with CD3D
STRUCTURE	9.48 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	weak, lymphoid-specific TATA-less proximal promoter :
	NFAT motifs in the proximal promoter positively or negatively regulating expression of CD3G by their differential binding of NFATc1 plus NF-kappaB p50 or NFATc2 containing complexes, respectively

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000073 7 - 1311 NP_000064 - 182 - 1998 9804841 PTAC12 - splicing - - - most T cells lineages 1998 9804841 lacking the TM segments (exon 4)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen           thymus         Nervous brain       moderately Respiratory lung         Urinary kidney tubule convoluted tubule

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Ig extracellular domain
	a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM), isoform TAC12, 12kDa
	three NFAT binding motifs (for NFATC1, NFATC2 and NFKB2)
	highly evolutionarily conserved CXXC motif
	a short extracellular stalk connecting its Ig-like domains to its transmembrane regions

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Cd3g
	homolog to C.elegans C02F5.5

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein

basic FUNCTION	mediating signal transduction
	the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane
	CD3G and CD3D evolved from a common precursor gene to optimize peptide/MHC-triggered alphabeta TCR activation
	important role of the CD3G diL motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

constituent of the CD3 (pre-T cell and T cell) antigen receptor complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IMD17

related resource

CD3Gbase: Mutation registry for autosomal recessive CD3gamma immunodeficiency

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients with aplastic anemia (AA)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS