Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

DLK1

contributors: mct - updated : 06-01-2016

HGNC name	delta-like 1 homolog (Drosophila)
HGNC id	2907

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

UPD14M , UPD14P , DEL14Q32

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in renal cell carcinoma by gain of methylation upstream of the untranslated MEG3 leading to pathological downregulation tumoral     --over   in GH-secreting (GH-S) pituitary tumors, and in gliomas tumoral     --over   in hepatocellular carcinoma, through deregulation of genomic DNA methylation of the imprinted domain

Susceptibility

to type 1 diabetes

Variant & Polymorphism

Candidate gene	associated with child and adolescent obesity
Marker
Therapy target

ANIMAL & CELL MODELS

	transgenic mice overexpressing soluble DLK1 in adipose tissue or liver show a marked decrease in adiposity, with reduced adipogenesis and adipocyte marker expression
	Dlk1(-/-) mice were developmentally retarded in their muscle mass and function owing to inhibition of the myogenic program during embryogenesis