| SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
|
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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| intracellular,nucleus
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| intracellular,nuclear envelope
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| basic FUNCTION
| involved in the phosphorylation of nucleoside diphosphates |
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acting as a transcription regulator for myc |
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interacting with membrane receptor and constituting a novel molecular regulatory mechanism of GPCR endocytosis |
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NME2 associates with telomerase and reduces telomerase activity, and sustained NME2 expression resulted in reduced telomere length in aggressive human cancer cells  |
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novel role for NME2 as a telomere binding protein that can alter telomerase function and telomere length |
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NME1, NME2 have likely differential abilities to modulate tumorigenesis |
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NME1 and NME2 have been identified as potential canonical transcription factors that regulate gene transcription through their DNA-binding activities |
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NME1, NME2 catalyze the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates by a ping-pong mechanism involving the formation of a high-energy phosphohistidine intermediate |
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NME2, can additionally act as a protein histidine kinase |
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addition of NME1 or NME2 to DNM2 facilitates DNM2 oligomerization and increases GTPase activity, both required for vesicle scission |
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critical role of NME2 in endothelial damage via the modulation of the hexosamine biosynthesis pathway (HBP) |
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NME1, but not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis |
