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FLASH GENE
Symbol SLC22A6 contributors: mct - updated : 03-05-2014
HGNC name solute carrier family 22 (organic anion transporter), member 6
HGNC id 10970
Location 11q12.3      Physical location : 62.744.069 - 62.752.469
Synonym name
  • para-aminohippurate transporter
  • renal organic anion transporter 1
  • PAH transporter
  • moderately similar to kidney-specific transport protein [M.musculus]
  • Synonym symbol(s) ROAT1, PAHT, OAT1, HOAT1, MGC45260, FLJ55736,
    DNA
    TYPE functioning gene
    STRUCTURE 8.40 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S1357 - SSRP1 - CNTF - OSBP - MS4A1 - MS4A2 - GIF GIF ,D11S1765 - AHNAK - CD5 - FTH1 - ROM1 - SLC22A6 - D11S1883 - FAU - D11S913 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2196 - 563 - Zalups (2004)
    also called OAT1-1
    10 splicing 2025 - 506 - Bahn, Zalups (2004)
    also called OAT1-3
    10 splicing 2064 - 519 - Bahn, Zalups (2004)
    also called OAT1-4
    10 splicing 2194 60.3 550 - Zalups (2004)
    also called OAT1-2
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland     Homo sapiens
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretoryrenal tubular epithelium   Homo sapiens
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten (? twelve) transmembrane segments protein
  • a large acidic cytoplasmic C terminal domain, having an essential role in the function of this transporter
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • polyspecific transporter for organic cations, including p-aminohippurate (PAH)
  • playing critical roles in the body disposition of environmental toxins and clinically important drugs
  • mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions
  • mediating the initial steps in the transport of organic anionic drugs between the blood and proximal tubule cells of the kidney
  • play crucial roles in the renal secretion of various drugs (Ogasawara 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • exists in the plasma membrane as a homooligomer, possibly trimer, and higher order of oligomer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL6 does not bind directly or indirectly to SLC22A6 promoter but increases the protein expression of HNF1A and thereby indirectly enhances SLC22A6 gene transcription
  • cell & other
    REGULATION
    Other SLC22A1, SLC22A6, SLC22A8 regulation during development and maturation of the kidney proximal tubule
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS