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FLASH GENE
Symbol SLC22A6 contributors: mct - updated : 03-05-2014
HGNC name solute carrier family 22 (organic anion transporter), member 6
HGNC id 10970
Location 11q12.3      Physical location : 62.744.069 - 62.752.469
Synonym name
  • para-aminohippurate transporter
  • renal organic anion transporter 1
  • PAH transporter
  • moderately similar to kidney-specific transport protein [M.musculus]
  • Synonym symbol(s) ROAT1, PAHT, OAT1, HOAT1, MGC45260, FLJ55736,
    DNA
    TYPE functioning gene
    STRUCTURE 8.40 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S1357 - SSRP1 - CNTF - OSBP - MS4A1 - MS4A2 - GIF GIF ,D11S1765 - AHNAK - CD5 - FTH1 - ROM1 - SLC22A6 - D11S1883 - FAU - D11S913 - qter
    Authors Gene Map (98)
    Physical map
    ROM1 11q13.1 retinal outer segment membrane protein 1 B3GAT3 11q12.2 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) G2AN 11q12.3 alpha glucosidase II alpha subunit KIAA1698 11q12.3 KIAA1698 protein MGC2477 11q12.3 hypothetical protein MGC2477 LOC51035 11q12.3 ORF LOC221091 11q12.3 similar to hypothetical protein BSCL2 11q12.q13.5 Bernardinelli-Seip congenital lipodystrophy 2 (seipin) GNG3 11p11 guanine nucleotide binding protein (G protein), gamma 3 DKFZp762N1910 11q12.3 hypothetical protein DKFZp762N1910 MGC29649 11q12.3 hypothetical protein MGC29649 ZBTB3 11q12.3 zinc finger and BTB domain containing 3 POLR2G 11q13.1 polymerase (RNA) II (DNA directed) polypeptide G TAF6L 11q13.1 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC387617 11 hypothetical gene supported by NM_018336 LOC374395 11q12.3 similar to RIKEN cDNA 1810059G22 NXF1 11q12-q13 nuclear RNA export factor 1 STX5A 11cen-q12.1 syntaxin 5A FLJ10439 11q12.3 hypothetical protein FLJ10439 SLC3A2 11q12-q22 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 CHRM1 11q12-q13 cholinergic receptor, muscarinic 1 SLC22A6 11q13.1-q13.2 solute carrier family 22 (organic anion transporter), member 6 SLC22A8 11q11.7 solute carrier family 22 (organic anion transporter), member 8 LOC390207 11 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC390208 11 similar to ribosomal protein L29 MGC34821 11q12.3 hypothetical protein MGC34821 LOC387601  putative UST1-like organic anion transporter CCND2P 11q13 cyclin D2 pseudogene LOC387775 11 similar to organic anion transporter 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2196 - 563 - Zalups (2004)
    also called OAT1-1
    10 splicing 2025 - 506 - Bahn, Zalups (2004)
    also called OAT1-3
    10 splicing 2064 - 519 - Bahn, Zalups (2004)
    also called OAT1-4
    10 splicing 2194 60.3 550 - Zalups (2004)
    also called OAT1-2
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland     Homo sapiens
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretoryrenal tubular epithelium   Homo sapiens
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten (? twelve) transmembrane segments protein
  • a large acidic cytoplasmic C terminal domain, having an essential role in the function of this transporter
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • polyspecific transporter for organic cations, including p-aminohippurate (PAH)
  • playing critical roles in the body disposition of environmental toxins and clinically important drugs
  • mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions
  • mediating the initial steps in the transport of organic anionic drugs between the blood and proximal tubule cells of the kidney
  • play crucial roles in the renal secretion of various drugs (Ogasawara 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • exists in the plasma membrane as a homooligomer, possibly trimer, and higher order of oligomer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL6 does not bind directly or indirectly to SLC22A6 promoter but increases the protein expression of HNF1A and thereby indirectly enhances SLC22A6 gene transcription
  • cell & other
    REGULATION
    Other SLC22A1, SLC22A6, SLC22A8 regulation during development and maturation of the kidney proximal tubule
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS