basic FUNCTION
| allowing diffusion of small hydrophilic molecules |
|
acting as an apoptogenic cytochrome c release channel |
|
mitochondrial porin, main pathway for metabolites across the mitochondrial outer membrane and that may serve as binding sites for kinases, including hexokinase |
|
acting as a NADH-ferricyanide reductase |
|
involved in the maintenance of cellular redox homeostasis |
|
playing a vital role in modulating ES-induced endothelial cell apoptosis |
|
involved in cell volume regulation |
|
may participate in the formation of the permeability transition pore complex responsible for the release of mitochondrial products that triggers apoptosis |
|
with others VDACs, are dispensable for both mitochondrial permeability transition and BCL2 family member-driven cell death |
|
mitochondrial porin, identified in the mitochondrial outer membrane that is able to form hydrophilic pore structures |
|
pore-forming proteins mainly located in the mitochondrial outer membrane |
|
roles in human sperm motility, capacitation and acrosomal reaction |
|
E72Q-VDAC1 has a dominant-negative effect and implies that VDAC1 homo-oligomerization, involving intermolecular interactions, might be involved in the apoptotic process |
|
most abundant protein in the mitochondrial outer membrane |
|
VDAC1, VDAC2, VDAC3 serve as mitochondrial docking sites to recruit PRKN from the cytosol to defective mitochondria |
|
VDAC1 and SLC25A4 have central roles in mitochondrial functions such as nucleotides transport and cell death |
|
VDAC1, VDAC2, and VDAC3, are pore-forming proteins that control metabolite flux between mitochondria and cytoplasm |
|
VDAC1, VDAC2, VDAC3 are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions |
|
VDAC1 oligomerization is a potential target for controlling apoptosis, specifically using drugs to induce apoptotic cell death in cancer and inhibit apoptosis in neurodegenerative diseases |
|
VDAC1 serves distinct functions as outer membrane channel for metabolites and as coupling factor for protein translocation into the inner membrane |
|
VDAC1 monoubiquitination plays important roles in the pathologies of Parkinson disease by controlling apoptosis |
|
general role for VDAC1, role as an actor of apoptosis for VDAC2, and the involvement in sex determination and development of VDAC3 |
|
important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate |
|
also participates in endoplasmic reticulum (ER)-mitochondria cross-talk, and in the regulation of autophagy, and inflammation |
|
crucial role for VDAC1 in human erythroblast terminal differentiation, regulating mitochondria clearance |