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FLASH GENE
Symbol RNF6 contributors: - updated : 18-12-2006
HGNC name ring finger protein (C3H2C3 type) 6
HGNC id 10069
Location 13q12      Physical location : 26.786.905 - 26.796.508
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
regionally located close to marker D13S1121 oriented from telomere to centromere
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3503 78 685 - Macdonald, 99
- splicing 3300 78 685 - Macdonald, 99
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
Reproductivefemale systemovary  lowly
 male systemprostate  lowly
 male systemtestis  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a coiled coil domain and a C terminal ring-H2 (C3H2C3) finger domain with a short KIL motif upstream of the RING domain
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY RING finger protein family
CATEGORY regulatory , transcription factor , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION potential tumor suppressor gene involved in the pathogenesis of esophageal squamous cell carcinoma.
CELLULAR PROCESS nucleotide, transcription, regulation
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA binding
RNA
small molecule metal binding,
zinc Zn2+
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS