| basic FUNCTION
| involved in transcriptional repression of HOX genes |
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involved in the maintenance of repression and the blocking of chromatin remodeling (Sathyamurthy 2003) |
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SCML2 participates likely in the epigenetic control of transcription directly and in cooperation with Polycomb repressive complex-1 (PRC1)  |
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RNF8 and SCML2 cooperate to regulate ubiquitination during meiosis, an early step to establish active histone modifications for subsequent gene activation |
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SCML2-dependent H3K27me3 in the male germline prepares the expression of developmental regulator and somatic genes in embryonic development |
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germline-specific Polycomb protein, as a critical regulator of heterochromatin organization in spermatogenesis |
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SCML2 is required for heterochromatin organization, and the loss of SCML2 leads to the formation of ectopic patches of facultative heterochromatin |
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coordinates likely the organization of heterochromatin and gene expression through the regulation of Polycomb complexes |
