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FLASH GENE
Symbol ALOX12 contributors: mct/npt - updated : 16-03-2011
HGNC name arachidonate 12-lipoxygenase
HGNC id 429
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • lipoxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • carcinogenesis and atheroma formation
  • cardiac ALOX12/ALOX15 is involved in the development of heart failure
  • ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
  • ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional link with ALOXE3 in normal differentiation of the epidermis
  • direct transcriptional target gene of RUNX1 (Kaur 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to modification of bone mineral density in postmenopausal women (BMD)
    Variant & Polymorphism other polymorphisms in ALOX12, significantly associated with BMD in postmenopausal women
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure
    ANIMAL & CELL MODELS