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FLASH GENE

Symbol

ALOX12

contributors: mct/npt - updated : 16-03-2011

HGNC name	arachidonate 12-lipoxygenase
HGNC id	429

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary       Skin/Tegument skin         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Lymphoid/Immune B cell

cell lineage
cell lines	erythroleukemia cells
fluid/secretion

at STAGE

physiological period

pregnancy

Text	umbilical vein

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

lipoxygenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	catalyzing the first step of leukotrienes biosynthesis from arachidonate
	lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
	carcinogenesis and atheroma formation
	cardiac ALOX12/ALOX15 is involved in the development of heart failure
	ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
	ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	functional link with ALOXE3 in normal differentiation of the epidermis
	direct transcriptional target gene of RUNX1 (Kaur 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to modification of bone mineral density in postmenopausal women (BMD)

Variant & Polymorphism other	polymorphisms in ALOX12, significantly associated with BMD in postmenopausal women

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure

ANIMAL & CELL MODELS