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FLASH GENE

Symbol

RBM6

contributors: mct/npt - updated : 12-10-2009

HGNC name	RNA binding motif protein 6
HGNC id	9903

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	137.09 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	see SEMA3F
Authors	in the TSG3B region

regionally located

located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005777 21 - 1999 NP_005768 - 1123 - Timmer (1999) long form, including exon 5 variant 1 - splicing - isoform 1 - - most abundant in lung normal tissue Timmer short, without exon 5, truncated

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	20 repeats of six AA in the N terminus region
	two RNA binding motifs (RNP1) flanking a C2C2 zinc finger motif
	the C terminal region
	a C2H2 zinc finger motif and a bipartite nuclear localization signal (NLS)

HOMOLOGY

intraspecies

homolog to DXS8237E

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

RNA binding protein 6

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     deleted in small cell lung carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS