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FLASH GENE
Symbol RBM6 contributors: mct/npt - updated : 12-10-2009
HGNC name RNA binding motif protein 6
HGNC id 9903
Location 3p21.3      Physical location : 49.977.476 - 50.114.684
Synonym name
  • lung carcinoma antigen 12
  • lung cancer protooncogene 11
  • lung cancer antigen NY-LU-12
    • Synonym symbol(s) g16, DEF3, LUCA12, 3G2, NY-LU-12, DKFZp686B0877, FLJ36517,HLC-11
    DNA
    TYPE functioning gene
    STRUCTURE 137.09 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see SEMA3F
    Authors in the TSG3B region
    regionally located located in a region duplicated for the Xp11.3-p11.23 region containing UBE1 and DXS8237E
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 1999 - 1123 - Timmer (1999)
    long form, including exon 5
    - splicing - - - most abundant in lung normal tissue Timmer
    short, without exon 5, truncated
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 20 repeats of six AA in the N terminus region
  • two RNA binding motifs (RNP1) flanking a C2C2 zinc finger motif
  • the C terminal region
  • a C2H2 zinc finger motif and a bipartite nuclear localization signal (NLS)
    • HOMOLOGY
    intraspecies homolog to DXS8237E
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION RNA binding protein 6
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    deleted in small cell lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS