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FLASH GENE
Symbol RBM5 contributors: mct - updated : 30-10-2017
HGNC name RNA binding motif protein 5
HGNC id 9902
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal region, with two RNA binding motifs (RNP1) flanking a C2C2 zinc finger motif
  • two RRM motif (RNA recognition motif) and the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing
  • in the C terminal region, a C2H2 zinc finger motif and a bipartite nuclear localization signal (NLS)
    • HOMOLOGY
    intraspecies homolog to DXS8237E
    paralog to RBM10
    Homologene
    FAMILY
    CATEGORY DNA associated , RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the control of apoptosis
  • may mediate apoptosis in a TP53-independent manner, acting as a post-transcriptional regulator for cell cycle/apoptotic-related proteins
  • nuclear SR-related RNA binding protein with the ability to modulate both apoptosis and the cell cycle, and retard tumour formation
  • regulates CASP2 alternative splicing and promotes the formation of proapoptotic CASP-2L isoform
  • having a role as an apoptosis regulator in cancer cells
  • functions as an alternative splicing regulator of apoptosis-related genes
  • is an essential regulator of haploid male germ cell pre-mRNA splicing and fertility
  • critical role for RBM5 as a pre-mRNA splicing regulator in round spermatids and male fertility
  • RNA binding activity of RBM5 contributes to its function on apoptosis induction and cell growth inhibition
  • nuclear protein that modulates gene transcription and mRNA splicing in cancer cells
  • may function as a tumor suppressor in medulloblastoma (MB) by regulating Wnt/CTNNB1 signaling
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • binds to CASP2 pre-mRNA
  • tumor suppressor gene that has been shown to function in cell growth inhibition by modulating apoptosis, and also plays a critical role in alternative splicing as an RNA binding protein
  • RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis-related genes, FAS and CFLAR
  • autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
  • RBM5 regulates likely RAB4A in neurons
  • RBM5 expression level was negatively related to the PCAT1 expression level in pancreatic cancer tissues
  • regulates alternative splicing of apoptotic genes including the cell death receptor FAS and the initiator CASP2
    • cell & other
    REGULATION
    Other regulated by reversible phosphorylation (mechanism capable of regulating RBM5 participation in modulating apoptosis, and perhaps tumour suppression)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    RBM5-enhanced autophagy acts in a cytoprotective way and inhibition of autophagy may improve the anti-tumor efficacy of RBM5 in lung cancer
    cancerdigestivepancreas
    PCAT1 acts as an oncogene in pancreatic cancer and promotes cell metastasis via inhibiting RBM5, which might be a novel therapeutic strategy in pancreatic cancer
    ANIMAL & CELL MODELS
  • mice carrying a missense mutation (R263P) in the second RNA recognition motif (RRM) of RBM5 exhibited spermatid differentiation arrest, germ cell sloughing and apoptosis, which ultimately led to azoospermia (no sperm in the ejaculate) and male sterility