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FLASH GENE
Symbol HNRPDL contributors: mct/npt - updated : 09-12-2005
HGNC name heterogeneous nuclear ribonucleoprotein D-like
HGNC id 5037
Location 4q13-q21      Physical location : 83.344.348 - 83.351.378
Synonym name
  • JKT41-binding protein
  • AU-rich element RNA-binding factor
  • Synonym symbol(s) JKTBP, HNRNP, JKTBP2, laAUF1, JKTBP1
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3510 46.4 420 - Kamei, Reboll (2007)
  • alternative splicing does not affect the coding region
  • encoding the same isoform than variant 2
  • - splicing 3409 46.4 420 - Kamei
  • alternative splicing does not affect the coding region
  • encoding the same isoform than variant 1
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two repeats of a putative RNA binding domain, RRM domains that bind to RNAs
  • a glycine- tyrosine-rich C terminus
  • a tyrosine phosphorylation site
  • two AU-rich element (ARE) RNA-binding motifs
  • conjugated RiboP
    HOMOLOGY
    interspecies ortholog to murine Hnrpdl
    homolog to drosophila sqd
    Homologene
    FAMILY
  • family of heterogeneous nuclear ribonucleoproteins (hnRNPs)
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text shuttles between the nucleus and the cytoplasm and interacts with mRNA.
    basic FUNCTION
  • influencing pre-mRNA processing and other aspects of mRNA metabolism and transport
  • mediating the activity of NKRF
  • function in mRNA biogenesis and mRNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    mRNA metabolism
    a component
  • complexing with heterogeneous nuclear RNA (hnRNA)
  • INTERACTION
    DNA binding to double-stranded and single-stranded DNA
    RNA binding to pre-mRNAs in the nucleus
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS