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FLASH GENE
Symbol SGK3 contributors: mct - updated : 21-11-2012
HGNC name serum/glucocorticoid regulated kinase family, member 3
HGNC id 10812
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PX (phox homology) domain
  • protein kinase C-terminal domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Sgk3
    intraspecies homolog to SGK1
    Homologene
    FAMILY
  • ser/thr protein kinase family, AGC family of kinases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in activating certain potassium, sodium, and chloride channels
  • may be involved in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion
  • phosphorylates FLII and activates nuclear receptor transcription, suggesting a new cell survival signaling pathway mediated by PI 3-kinase and GSK3
  • SGK3 and AKT2 both appear to play potentially important roles in postnatal hair follicle morphogenesis
  • SGK1/SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
  • has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density
  • plays a previously unappreciated role in glucose homeostasis, likely through direct effects within beta-cells, to stimulate proliferation and insulin release, at least in part by controlling the expression and activity of CTNNB
  • functions downstream of the PI 3-kinase cascade and shares molecular and biochemical similarities with AKT
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NEDD4 and NEDD4L
  • regulating BSND and participating in the regulation of transport in kidney and inner ear
  • interacting with SGK and SLC6A8 (increase SLC6A8 activity by increasing the maximal transport rate of the carrier)
  • SGK1, SGK2, SGK3 participate in the regulation of KCNE1-dependent transport and excitability
  • FLII is a substrate of SGK3 that functions downstream of PI 3-kinase and SGK3 can associate with FLII and phosphorylate FLII at residues Ser(436) and Thr(818)
  • SGK1, SGK2, SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
  • novel endosomal kinase that acutely regulates SLC9A3 in a PI3K-dependent mechanism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking SGK3 have abnormal follicle cycling, which begins shortly after birth and ameliorates substantially with age; however, this developmental abnormality is not recapitulated in mice lacking closely related kinases Akt1, Akt2, or Akt3