Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SGK3

contributors: mct - updated : 21-11-2012

HGNC name	serum/glucocorticoid regulated kinase family, member 3
HGNC id	10812

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001033578 17 splicing 4483 NP_001028750 57 496 - 1999 10585774 differs in the 5' UTR compared to variant 1 NM_013257 17 - 4206 NP_037389 57 496 - 1999 10585774 NM_170709 16 splicing 4110 NP_733827 53 464 - 1999 10585774 lacking an alternate in-frame exon NM_001204173 16 - 4563 NP_001191102 57 496 - 1999 10585774

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	PX (phox homology) domain
	protein kinase C-terminal domain

conjugated

PhosphoP

HOMOLOGY

interspecies

ortholog to murine Sgk3

intraspecies

homolog to SGK1

Homologene

FAMILY

ser/thr protein kinase family, AGC family of kinases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus

basic FUNCTION	playing an important role in activating certain potassium, sodium, and chloride channels
	may be involved in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion
	phosphorylates FLII and activates nuclear receptor transcription, suggesting a new cell survival signaling pathway mediated by PI 3-kinase and GSK3
	SGK3 and AKT2 both appear to play potentially important roles in postnatal hair follicle morphogenesis
	SGK1/SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
	has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density
	plays a previously unappreciated role in glucose homeostasis, likely through direct effects within beta-cells, to stimulate proliferation and insulin release, at least in part by controlling the expression and activity of CTNNB
	functions downstream of the PI 3-kinase cascade and shares molecular and biochemical similarities with AKT

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with NEDD4 and NEDD4L
	regulating BSND and participating in the regulation of transport in kidney and inner ear
	interacting with SGK and SLC6A8 (increase SLC6A8 activity by increasing the maximal transport rate of the carrier)
	SGK1, SGK2, SGK3 participate in the regulation of KCNE1-dependent transport and excitability
	FLII is a substrate of SGK3 that functions downstream of PI 3-kinase and SGK3 can associate with FLII and phosphorylate FLII at residues Ser(436) and Thr(818)
	SGK1, SGK2, SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
	novel endosomal kinase that acutely regulates SLC9A3 in a PI3K-dependent mechanism

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking SGK3 have abnormal follicle cycling, which begins shortly after birth and ameliorates substantially with age; however, this developmental abnormality is not recapitulated in mice lacking closely related kinases Akt1, Akt2, or Akt3