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FLASH GENE
Symbol MPDU1 contributors: mct/npt - updated : 18-09-2009
HGNC name mannose-P-dolichol utilization defect 1
HGNC id 7207
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential member spanning segments
  • likely C terminal endoplasmic reticulum retention signal
  • two PQ-loop domains
    • HOMOLOGY
    interspecies ortholog to rattus Mpdu1 (87.9pc)
    ortholog to murine Mpdu1 (90.7pc)
    Homologene
    FAMILY
  • MPDU1 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text cytosilic C and N termini
    basic FUNCTION
  • required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring (Anand (2001)
  • controls an aspect of mannose-P-dolichol (MPD) orientation in the endoplasmic reticulum membrane that is crucial for its activity as a donor substrate (Anand 2001)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1F
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS