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FLASH GENE

Symbol

ATP4B

contributors: - updated : 25-02-2006

HGNC name	ATPase, H+/K+ exchanging, beta polypeptide
HGNC id	820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial barrier/lining uroepithelium     Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Atp4b
	homolog to C.elegans F55F3.3

Homologene

FAMILY	P-type cation-transporting ATPases
	sodium/potassium Na+/K+ and hydrogen H+ ATPases beta chain family

CATEGORY

enzyme , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	Type II membrane protein

basic FUNCTION

proton pump responsible for stomach lumen acidification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	beta subunit of gastric hydrogen/potassium H+/K+ exchanging ATPases
	heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS