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FLASH GENE
Symbol ATP4B contributors: - updated : 25-02-2006
HGNC name ATPase, H+/K+ exchanging, beta polypeptide
HGNC id 820
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
text structure
  • a single GATA protein binding site near the TATA box, recognized by the zinc finger domain of GATA-6
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Atp4b
    homolog to C.elegans F55F3.3
    Homologene
    FAMILY
  • P-type cation-transporting ATPases
  • sodium/potassium Na+/K+ and hydrogen H+ ATPases beta chain family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text Type II membrane protein
    basic FUNCTION
  • proton pump responsible for stomach lumen acidification
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • beta subunit of gastric hydrogen/potassium H+/K+ exchanging ATPases
  • heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS