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FLASH GENE
Symbol GPC6 contributors: mct/np - updated : 25-05-2013
HGNC name glypican 6
HGNC id 4454
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • anchored to the membrane via a glycosyl phosphatidylinositol anchor, with 13 cysteines at conserved position
    • HOMOLOGY
    intraspecies homolog to GPC4
    Homologene
    FAMILY
  • GPI- linked-glypican family
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in cellular growth control and differentiation
  • cell surface proteoglycan that bears heparan sulfate
  • putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases
  • playing a role in enchondral ossification and long-bone elongation (Campos-Xavier 2009)
  • astrocyte-secreted signals sufficient to induce functional synapses between purified retinal ganglion cell neurons
  • GPC4 and GPC6 are astrocyte-derived molecules necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel NFATC1, NFATC2, NFATC3, NFATC4 target gene in breast cancer cells that promotes invasive migration through WNT5A signalling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OMD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS